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Sens. Rand Paul and Ted Cruz have announced they'll run for president, and Hillary Clinton is expected to announce on Sunday. Correspondents Mara Liasson and Don Gonyea join NPR's Tamara Keith.

Scientists are trying to develop drugs to counteract an "undruggable" genetic variant that's responsible for about 30 percent of all cancer cases. It's high risk — high reward research.

Jason Musgrove has been in agony for more than a week. He's had no contact from his 69-year-old mother, who has mobility issues. She was last seen escorted out of her apartment building on Aug. 8.

Set in 1960s New Orleans, A Confederacy of Dunces centers around Ignatius J. Reilly, a glutton in a city known for its cuisine. A new cookbook looks at the food central to the heralded comedic novel.

Jonathan Balcombe, author of What A Fish Knows, says that fish have a conscious awareness — or "sentience" — that allows them to experience pain, recognize individual humans and have memory.

The Fox News host tells Fresh Air that she worries about Trump's "de-legitimization" of the media. "Too many millions of Americans aren't listening at all to what the press tells them," Kelly says.

Some health systems are encouraging selected emergency room patients who are sick but stable and don't need intensive, round-the-clock care to opt for hospital-level care at home, instead.

Hugging a doll can soothe an upset toddler, and some say it can do the same for people with dementia. But critics say this form of therapy infantilizes adults.

Idalia made landfall near Keaton Beach, Fla., as a Category 3 hurricane on Wednesday, gradually weakening as it ripped through the state, into Georgia and across the Carolinas.

Christian Picciolini spent eight years as a member of a violent, white power skinhead group. He eventually withdrew and co-founded a nonprofit to help extremists disengage.