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Handcuffed and under Iraqi guard, Saddam Hussein is charged with war crimes, genocide and crimes against humanity before an Iraqi court. Saddam questioned the court's jurisdiction and refused to sign the charge list. Earlier, Lt. Gen. Ricardo Sanchez relinquished leadership of the multinational force in Iraq to Gen. George Casey. Hear NPR's Steve Inskeep and NPR's Philip Reeves.

In the Darfur region of Sudan, thousands of people have died and a million have been driven from their homes as result of what many are calling ethnic cleansing or even genocide. Hear NPR's Susan Stamberg, photographer Marcus Bleasdale, and Dr. Jennifer Leaning of Physicians for Human Rights.

Mississippi Gov. Haley Barbour is expected to sign a tort reform bill Wednesday that would place limits on the amount a jury can award plaintiffs for pain and suffering in medical malpractice suits. It also would cap the liability that companies can face. Some question whether the measure amounts to necessary legal reform or protection for corporations. NPR's Jack Speer reports.

The Department of Homeland Security raises the terror alert level in Washington, New York and New Jersey. Homeland Security chief Tom Ridge says financial institutions like the New York Stock Exchange and the International Monetary Fund could be targeted. NPR's Libby Lewis reports.

The Sept. 11 commission is expected to call for a new chief to coordinate the nation's intelligence efforts. Three former CIA directors NPR spoke to disagree over the need for a "czar" to oversee intelligence efforts, but all warn against rapid reforms in the middle of the war on terror -- and the presidential campaign. Hear NPR's Mary Louise Kelly.

President George Bush and Democratic challenger Sen. John Kerry take their campaigns to Davenport, Iowa, Wednesday. In speeches to voters, Kerry discussed jobs and the economy and the president spoke of the war on terror. Hear NPR's Melissa Block, NPR's Don Gonyea and NPR's Scott Horsley.

The U.S. government is sending 20,000 talking books to Afghanistan in an effort to improve maternal and child health. The country has the world's highest maternal mortality rate, and statistics for children are even grimmer. NPR's Julie Rovner reports.

Government investigators continue poring over the documents and photographs that led to this week's terror warnings, some of them from a laptop computer seized in Pakistan. The files reportedly contain detailed information about financial institutions in New York City, Newark and Washington, DC. Hear Homeland Security advisor Frances Townsend and NPR's Michele Norris.

President Bush nominates Rep. Porter Goss (R-FL) to direct the Central Intelligence Agency. Goss is chairman of the House Intelligence Committee and a past CIA officer. But his political background has lead to concerns of a confirmation battle. NPR's Mary Louise Kelly reports.

In a one-day visit to Afghanistan, Defense Secretary Donald Rumsfeld praises the country's efforts to register voters ahead of the October elections. Addressing Afghanistan's booming opium production, Rumsfeld says U.S. forces will step up their efforts to crack down on the country's drug trade. Hear NPR's Renee Montagne and reporter Rachel Martin.